Palazzo Mazzetti is the most beautiful eighteenth-century stately home in Asti. Located in the ancient centre, along Corso Alfieri, the medieval main road, the building is at the center of a route of great interest, which tells the story of the city and the territory on a thematic basis through sites of historical-artistic interest. Begun in the last quarter of the seventeenth century and enlarged based on a design by the architect Benedetto Alfieri in the years 1751-1752, over the centuries the palace hosted personalities such as Giacomo Stuart (1717), the king of Sardinia Charles Emmanuel III (1727) and Napoleon I (1805).

Purchased in 2000 by the Cassa di Risparmio di Asti Foundation, with the aim of creating an important center of cultural attraction, the building was returned to the city in December 2011, completely recovered and with a renewed layout of the civic collections and exhibition spaces temporary. Equipped with a bookshop, classroom, conference room, library, archives, storage, cafeteria, touch screen and multimedia projections, the ancient residence is full of charm. Walking through the building, from the underground floor to the top floor which houses the nineteenth-twentieth century paintings and sculptures, one can grasp significant elements of historical and construction events and, through the museum layout, understand the formation of the collections in recent years from the nineteenth century until today.