In a sumptuous domestic interior, the Madonna receives the announcement of her divine motherhood from the angel, an episode narrated in the Gospels of Luke and Matthew. The triple arch in the background frames the characters in the foreground and accelerates the telescope perspective that opens onto a hortus conclusus, the pristine garden, symbol of Mary's virginity. At the far right, two maids peep out, almost frightened by the presence of the unexpected visitor. On the far right the donors, reserved witnesses of the scene. The golden embroidery of the fabrics, the arabesques and plant motifs on the furnishings, the wings and locks of the angel's hair, the mottled marbles of the columns, are rendered with extreme detail, which denotes a knowledge and influence of contemporary Flemish painting (equally evident in the Madonna of Tarquinia, exhibited in the same room). Probably the table was originally placed in the chapel of a church as an altarpiece. The empty space that opens in the lower center could have been in dialogue with the real space of the chapel, perhaps a figurative extension of steps where the faithful prayed.