The 16th century triumphal arch, perhaps erected by Orazio Malaguzzi, introduces a tree-lined boulevard leading to the Mauriziano Palace: despite the renovations of the '600 -' 700 the building maintains its renaissance structure.
The interior paintings, made after 1567, are influenced by Nicolò dell'Abate: in the "Poet’s chamber" ancient and modern painters are depicted, and scenes from the "Decameron"; in the room traditionally believed to be "Ariosto’s  study", the paintings’ topic is the the villa with its garden.
The last room, in honor of Orazio Malaguzzi, narrates of Horatius Cocles, while in the hall the ‘700 frescoes tell stories of the family.                                                                               
From 1522, following the trend for the "antiquities gardens", Malaguzzi added to the garden various Latin inscriptions found nearby, which are now preserved in the Palazzo dei Musei in Reggio Emilia. The Municipality of Reggio Emilia purchased the house from the Malaguzzi family in 1863.
Poet Ludovico Ariosto spent his childhood at the Mauriziano, and returned several times: he maintained relations with his maternal family of the Malaguzzi, and he remembered with pleasure those places, as in satire IV: "Your Mauricïan I always dream, the beautiful room, the nearby Rhone, beloved shady seat of the Naiads ".
A bust of the poet is on the façade of the building.