The National Archaeological Museum of Umbria, also known as MANU, has been located since 1948 in the architectural complex of San Domenico.

The exhibition path of the Museum includes seven itineraries that range from prehistory to Roman times, passing through the Umbrians and Etruscans.

Since 2009, a profound renewal has been initiated in the contents and exhibition, especially in light of new acquisitions, such as the Tomb of the Cacni.

There is a room with the amulets of the Bellucci Collection, the Numismatic Cabinet, and the exhibition of Goldsmithing and small coin treasures.

In 2017, the National Archaeological Museum of Umbria hosted European-level exhibitions (Celts of Bratislava; Grimm Museum. Amulets and fairy tales of Umbria) and national exhibitions (Museum Games. Ancient and modern toys); exhibitions related to museum collections (including: Wardrobe 16; Astronomical instruments; Musical instruments); international conferences mainly focused on Etruscan culture and annual conference programs (also scheduled for 2018), including The Archaeologist's Profession; periodically guided theme tours are offered.

In March 2018, a new section dedicated to inscriptions on everyday objects was inaugurated.