Renaissance building built by Federico da Montefeltro and built by the architect Francesco di Giorgio Martini. Inside are the replication of the study of Frederick (whose wooden apparatuses are located at New York's Metropolitan Museum), some original furniture, a collection of paintings (XIII-XVIII century), the remains of medieval structures; on the upper floors the winning works of the Biennale of Contemporary Art in Gubbio are visible. The Palace has hosted exhibitions (such as: Light Art, part of Lightquake project 2017, until 25 February 2017; Giuseppe Magni and majolica of historicism, until 20 May 2018; fantastic Middle Ages; Imbilico. Perpetua motus ground), events (like Palazzo Ducale Wedding), courses (such as historical fencing), educational workshops. Federico's flames inspired a line of leather goods dedicated to the Palazzo da Vodivì.
In March 2018 the permanent exhibition of the Otto Tavolette by Taddeo di Bartolo was inaugurated.