The fresco occupies the east wall of the Chapel Gallery and is associated with the theme of Hercules defeating Cerberus, represented on the opposite wall. Both events were well known and could count on a solid visual tradition of reference. According to Greek mythology Prometheus was punished by Zeus for stealing fire from the gods to deliver it to men. In the scene of the Torment Prometheus is represented tied to the ground with chains, while a bird of prey tears his liver.